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Common and rare SCN A variants may contribute to
2019-05-28

Common and rare SCN10A variants may contribute to AF susceptibility [59,60]. SCN10A mutations (R14L and R1268Q) cause a loss of function of Nav1.5 current, which is expected to reduce excitability and lead to the development of the arrhythmogenic substrate responsible for BrS and AF. A common varian
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We have received funding from the Wellcome Trust to develop
2019-05-28

We have received funding from the Wellcome Trust to develop a global atlas of podoconiosis. We aim to advance new knowledge on the geographical distribution and spatial epidemiology of the disease. A first step in this work will be to establish the geographical absence of disease by applying an evid
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Hereditary syndromes with increased risk for
2019-05-28

Hereditary syndromes with increased risk for gastric cancer include: 1) hereditary diffuse gastric cancer, 2) Lynch syndrome/hereditary non-polyposis colorectal cancer, 3) juvenile polyposis syndrome, 4) Peutz-Jeghers syndrome and 5) familial adenomatous polyposis. Hereditary diffuse gastric cancer
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fluoxetine hydrochloride br Postoperative rehabilitation Alt
2019-05-28

Postoperative rehabilitation Although surgery is the main curative therapy for lung cancer, the procedure can directly cause a reduction in pulmonary functional reserve and exercise capacity proportional to the extent of resection. The problems might be more severe in those undergoing multimodali
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To date over mutations in KCNQ have been found to
2019-05-28

To date, over 250 mutations in KCNQ1 have been found to be linked to LQT1 [34] and new LQT1 causing mutations continue to be identified. The vast majority of KCNQ1 mutations are single nucleotide substitutions (missense) or small insertion/deletions that localize to the S1-S6 transmembrane domains [
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br D microCT data Bone
2019-05-27

3D microCT data Bone volume (BV/TV) ranged from 10.8 to 13.5% consistent with the published literature [18]. Trabecular thickness (Tb.Th), trabecular the aroma of oil (Tb.Sp), trabecular number (Tb.N) and bone surface per tissue area (BS/TV) values were also consistent with the range published in
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Desde la perspectiva expuesta la etnicidad constituye una
2019-05-27

Desde la perspectiva expuesta, la etnicidad constituye una dimensión potencial de la identidad, fundamentada en un conjunto de elementos que, al seguir la tradición weberiana, pueden abarcar la percepción de origen, cultura, idioma o rasgos fenotípicos compartidos por un conjunto de personas. La adq
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Los aportes de la escuela francesa constituyen
2019-05-27

Los aportes de la escuela francesa constituyen su núcleo central. La formación militar de argentinos por franceses data de 1955. En 1957 el coronel Carlos Rosas, egresado de la Escuela Francesa, asumió la subdirección de la Escuela Superior de Guerra y en 1959 se suscribieron una serie de convenios
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br Clinical characteristics Brugada syndrome is
2019-05-27

Clinical characteristics Brugada syndrome is more common in Southeast Asia, including Japan, with an estimated prevalence of 12 in 10,000 individuals, compared with Western countries where the estimated prevalence is 1 to 5 in 10,000 individuals. However, the incidence of early repolarization sy
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The long term goal of independence of recipients and
2019-05-24

The long-term goal of independence of recipients and sustainability of projects must remain at the forefront of all programmes. The post-2015 Sustainable Development Goals (SDGs) have been criticised as being too general and impractical, and as we move into the SDG era this study has identified a ne
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What lies ahead Clearly the extremely ambitious goals
2019-05-24

What lies ahead? Clearly the extremely ambitious goals and targets set by the UNCoLSC have not been reached, and challenges must be overcome. While the current evaluation highlights several challenges and strategies for action, a clear process in moving forward would be to link this bottleneck analy
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br Signal averaged electrocardiography SAECG SAECG is a high
2019-05-24

Signal-averaged electrocardiography (SAECG) SAECG is a high-resolution electrocardiographic technique developed in the 1970s for detecting patients who are prone to SCD after MI. It is based on the theory that lethal ventricular arrhythmias leading to SCD often have a reentrant mechanism. Reentry
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Long marginalised as a disorder confined to
2019-05-24

Long marginalised as a disorder confined to specific racial groups, sickle-cell disease is now assuming its rightful place as a major global public health problem. Most patients in the Americas, the Caribbean, and much of Europe have been of one racial group, which led to the common misconception th
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br Methods br Results br Discussion Bisphosphonates
2019-05-23

Methods Results Discussion Bisphosphonates reduce skeletal morbidity in patients with advanced cancers involving bone and have become a recommended component of the multidisciplinary treatment of MBD [1]. However, bone-health benefits have not generally translated into significantly improve
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The methods used for this purpose are substantially
2019-05-23

The methods used for this purpose are, substantially, the analyses of atrial potentials, evoked atrial potentials [10], and ventricular rhythm in cases of stable spontaneous AV conduction [11]. Materials and methods Results Discussion This is the first report on the current ACAP Confirm® r
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