• To verify DNA glycosylase AP lyase activity we have employed

  2022-06-23

  

  To verify DNA glycosylase/AP lyase activity we have employed a simple and efficient method to investigate based on fluorescein-labeled duplex oligonucleotides read on an automated sequencer (Allgayer et al., 2013, Lopes et al., 2007, Lopes et al., 2008). This approach using purified CpMutY proteins

• A considerable body of evidence suggests that alcohols volat

  2022-06-23

  

  A considerable body of evidence suggests that alcohols, volatile anesthetics and inhaled drugs of abuse act at discrete sites on glycine and GABAA receptors, specifically within circumscribed protein pockets (Mascia et al., 2000, Mihic et al., 1997, Beckstead et al., 2000). An amino Schisandrol B re

• In conclusion we demonstrated that the atypical high basal a

  2022-06-23

  

  In conclusion, we demonstrated that the atypical high-basal activity of the mGlu3 A939572 results mostly from its activation by low ambient glutamate concentrations. This is due to a unique interaction network located in the extracellular domain of the mGlu3 receptor. This network acts as “Cl− lock”

• It is an aspiring task to apply the glutamate

  2022-06-23

  

  It is an aspiring task to apply the glutamate biosensor for in vivo measurements in silybin sale tissue. Due to a relatively large size of the electrode used in this work, the biosensor fits only ex vivo applications. However, it is possible to apply platinum microelectrodes 50–100 μm in diameter f

• L-Kynurenine mg br Acknowledgements br Introduction Aminoacy

  2022-06-23

  

  Acknowledgements Introduction Aminoacyl-tRNA synthetases catalyze the formation of an ester bond between an amino L-Kynurenine mg and the 3′ end of a tRNA in a two-step reaction. First, the amino acid is activated and an enzyme-bound adenylate intermediate is formed. Then, the amino acid is t

• Introduction Human pathogenic Leishmania protozoa comprise

  2022-06-23

  

  Introduction Human pathogenic Leishmania protozoa comprise 20 different species that are distributed throughout the world and cause the disease leishmaniasis [1]. Transmission primarily occurs through the bite of a female sand fly and clinical manifestations of the disease span from cutaneous lesio

• Recent studies have elucidated a profound role for FFA in

  2022-06-22

  

  Recent studies have elucidated a profound role for FFA4 in modulation of metabolism and energy utilization as well as endocrine and immune function, and as a consequence, have thrust FFA4 to the forefront of drug discovery efforts. For example, activation of FFA4 by fatty sevelamer hcl receptor or

• To date the underlying mechanism of ropivacaine in inducing

  2022-06-22

  

  To date, the underlying mechanism of ropivacaine in inducing neurotoxicity remains unclear. Cell death was intimately involved in local-anesthetic neurotoxicity [6,18]. Two classic signaling pathways triggered cell death: the extrinsic pathway and the intrinsic pathway [12]. Our study demonstrated t

• Over the last decade intense efforts have been

  2022-06-22

  

  Over the last decade, intense efforts have been devoted toward identifying IN inhibitors as potential drugs against HIV. Raltegravir and elvitegravir are integrase strand transfer inhibitors (INSTIs) that have been approved for therapy and dolutegravir is another INSTI that is currently in advanced

• Different crystal structures of both HOs were reported and

  2022-06-22

  

  Different crystal structures of both HOs were reported and showed that the three-dimensional structures of proteins (HO-1: PDB code 1N45, HO-2: PDB code 2QPP) are predominantly in an α-helical conformation, with the heme packed between two helices (distal and proximal), and present a remarkable stru

• The Hedgehog signaling pathway HH pathway hereafter is vital

  2022-06-22

  

  The Hedgehog signaling pathway (HH pathway hereafter) is vital for development and tissue homeostasis. [4] In recent years, studying the role of the HH pathway in carcinogenesis and cancer stemness has highlighted the HH inhibitors as putative cancer therapeutics [5]. However, clinical application o

• br Direct effect of HDACs

  2022-06-22

  

  Direct effect of HDACs on contractile function by deacetylating cytoskeletal and contractile proteins Role of HDACs in electropathology by transcriptional reprogramming Next to deacetylation of α-tubulin by HDAC6 in experimental and human AF, there is also evidence for transcriptional reprogra

• It was revealed that various injured or infected

  2022-06-22

  

  It was revealed that various injured or infected organs of Hippeastrum produce a mixture of an orange-colored chalcone and flavans which can be oxidized to red-colored dimer (Wilmowicz et al., 2014, Wink and Lehmann, 1996), preventing the penetration of injured tissues by Phoma narcissi, Botrytis ci

• Interestingly studies from Sahai and

  2022-06-22

  

  Interestingly, studies from Sahai and colleagues in cancer-associated fibroblasts have revealed that YAP is required for the acquirement of a stiff ECM in the tumor microenvironment (Calvo et al., 2013). Subsequently, this stiffening of the matrix can activate YAP, thus creating a feed-forward loop.

• br Materials and methods br Results

  2022-06-22

  

  Materials and methods Results Discussion Metabolic abnormalities and systemic immune dysfunctions are common during HIV infection and/or antiretroviral therapy. Although some transcriptomic studies of HIV infection have revealed global changes in the mRNA and microRNA expression profiles (R

10872 records 113/725 page Previous Next First page 上5页 111112113114115 下5页 Last page